Abstract: This study was done in order to study the effect of IV injection of hyoscine upon delivery progression. This double blinded clinical trial study was done on 140 term, cephalic presentation pregnant women who have not natural vaginal delivery were admitted in Kosar hospital in autumn 1388 for pregnancy termination. A sample was selected based on inclusion and exclusion criteria and randomized divided into two groups, 20 mg (l mL) hyoscine was given to group one and l mL distilled water was given to control group (group 2). These IV injections were done as single dose at the beginning of active labor. After that duration of the 1st, 2nd and 3rd stages of labor, maternal complications and caesarean section rate during labor and APGAR scores in the neonates were recorded. Then data was analysis by Chi-square (χ2) and t-test. The mean time for the 1st stage in the control group was 113.5±47.2 min, compared with 100.64±48.3 min in the hyoscine group that was statistically significant (p = 0.045). There was no significant change in the duration of the 2nd and 3rd stages of labor and no difference in APGAR scores noted at 1 and 5 min, there was a slight (but statistically insignificant) increase in the caesarean section rate. No adverse effect was noted in the group of women receiving hyoscine, compared with the control group. Hyoscine butyl bromide is effective in significantly reducing the duration of the 1st stage of labor and it is not associated with any obvious adverse outcomes in mother or neonate.
Faride Movahed, Talaat Dabaghi Ghaleh, Fatemeh Lalooha, Samaneh Aziziyan and Omid Mashrabi, 2011. Effects of Hyoscine on First Stage of Labor in Full Term Pregnancy. Research Journal of Biological Sciences, 6: 648-651.