Authors : Naser Gharebaghi, Navid Atarod, Ehsan Jelodari, Negar Hoseinzadeh and Mohammad Ali Mohammad Nezhady
Abstract: Several line of evidences have been suggested that iron is critical for mycobacterium tuberculosis growth in macrophage and plays some role in the susceptibility to and outcome of tuberculosis. In view of the increasing burden of tuberculosis and lack of known risk factors for activation of tuberculosis in some cases, the researchers decided to study this relationship using iron indicating serum markers. In a case control study, 52 patients with pulmonary and extra pulmonary TB and without any known risk factor for tuberculosis activation compared with healthy subjects for serum iron, TIBC and ferritin level and transferrin saturation rate. A total of 52 TB patients 24 with pulmonary and 28 with extrapulmonary TB and 52 healthy individuals as control group were enrolled in the study. Mean serum ferritin level ±SD for case and control groups were 215.95±204.37 μg dL-1 and 61.67±45.8 μg dL-1, respectively. Mean±SD for serum iron level in case group was 62.88±30.41 μg dL-1 and for control was 86.75±27.56. Mean±SD for TIBC in case and control groups were 270.21±62.98 μg dL-1 and 231.71±48.57 μg dL-1, respectively. Mean±SD for transferrin saturation in case group was 23.63±10.87% and in control was 27.15±8.99%. The levels of iron, TIBC and ferritin showed significant difference in 2 groups but there was no significant difference about levels of transferrin saturation rate.
Naser Gharebaghi, Navid Atarod, Ehsan Jelodari, Negar Hoseinzadeh and Mohammad Ali Mohammad Nezhady, 2012. Evaluation of Relationship Between Iron Status and Pulmonary and Extra Pulmonary Tuberculosis: A Case-control Study. Research Journal of Biological Sciences, 7: 312-315.