Authors : Sedighe Forouhari, Zahra Ghaemi, Mohammad Hosein Dabbaghmanesh, Faride Vaziri, Zohreh Tavana and Mehrab Sayyadi
Abstract: Preeclampsia, a pregnancy-related condition that its specific etiology still remains obscure is recognized as the leading cause of morbidity and mortality in mothers and babies. Considering this, finding an index for predicting and preventing it seems vital. This study was designed by considering the theory of oxidative stress in the pathogenesis of preeclampsia and the role of selenium as an antioxidant in the prevention and detection of preeclampsia and the aim of determining the prognostic value of plasma selenium levels in the diagnosis of preeclampsia. In a nested case control study, a random sample of 600 normal primigravida in their 1st 24-28 weeks by screening participated in the study and the first blood sampling was performed on them. These blood samples after centrifugation for separating plasma were frozen in special freezers at temperatures of 70°C. After 3 months follow-up of all subjects, 39 of the participants developed preeclampsia. They formed a case group and second phase of blood sampling was performed on them. Among remaining subjects those that till 48 h after gestation were healthy with matching gestational age and receiving supplemental in a systematic method formed the controls and the second phase of blood sampling was performed. After delivery of all 600 pregnant, the amount of selenium in blood samples of first and second case and control groups was measured. Calculated odds ratio showed that the odds for people with selenium <62.2 for being affected by preeclampsia were 9.52 times more compared with people with average selenium. Accordingly, the best cut point was estimated 66.1 μg L-1 with sensitivity of 57.9% and specificity of 90.
Sedighe Forouhari, Zahra Ghaemi, Mohammad Hosein Dabbaghmanesh, Faride Vaziri, Zohreh Tavana and Mehrab Sayyadi, 2012. Ability to Determine the Prognostic Value of Plasma Selenium Levels in the Diagnosis of Preeclampsia. Research Journal of Biological Sciences, 7: 92-96.