Abstract: The aim of this study is to give a review of the current knowledge about the Heat shock protein 90 (Hsp90) and its relation with human reproduction. Hsp90 is a chaperone and conserved protein. It accounts for about 1-2% of total proteins. There are 2 isoforms of Hsp90: Hsp90α and β. The contribution of Hsp90 isoforms to various cellular processes including signal transduction, protein folding, protein degradation, cell survival and morphological evolution has gained high interest. The idea of considering infertility as an autoimmune disease is exciting. Various studies have demonstrated antiovary antibodies against Hsp90. In this study, such concepts and their implications have been reviewed.
Jehan Hamadneh, Ahed Jumah Alkhatib, Geir Bjorklund, Saleh A. Alrasheidi, Shereen Hamadneh, Mahmoud Banihani, Liqaa A. Raffee and Khaled Zayed Alawneh, 2014. The Role of Heat Shock Protein 90 in Human Reproduction. Research Journal of Biological Sciences, 9: 161-164.