Authors : Samia A.A. Hassan , Sania A.I. Shaddad , I.B. ElTayeb , M.A. Omer , M.H. Al-Nazawi and A.M. Homeida
Abstract: A total of 12 healthy desert sheep were injected intramuscularly with multiple doses of 5 g kg-1 tylosin. Samples were collected at time 1, 3, 7 and 10 days after drug administrations. Tylosin was detected using microbiological method. Tylosin concentrations in different tissue were detected. High concentration of 61.78�5.83, 315.97�73.07 and 3956�645.59 �g g-1 were detected in liver, kidney and muscle, respectively at day 1. The highest concentrations of 19185�2966.9 �g g-1 were noted at the site of injection at day 1 and persisted for 10 days. Low concentrations of 1.00, 1.5�0.24 and 5.22�0.20 �g g-1 were noted in the liver, kidney and muscle at day 10, respectively. It is suggested that high tissue levels may create a reservoir of drug from which drug was released slowly into the circulation.
Samia A.A. Hassan , Sania A.I. Shaddad , I.B. ElTayeb , M.A. Omer , M.H. Al-Nazawi and A.M. Homeida , 2008. Detection of Tylosin Residue Levels Following Intramuscular Injection in Desert Sheep. Research Journal of Pharmacology, 2: 1-3.