Authors : M.H. Al-Nazawi and A.M. Homeida
Abstract: The pharmacokinetics of salinomycin following oral administration of 0.1 μg kg-1 body weight was studied in camels. Peak plasma concentration occurred at 40 min and decline after 2 h to fall below the limit of assay detection at 16 h post-dosing, with terminal half-life of 150 min. Animals given salinomycin at doses of 0.4-0.8 μg kg-1 orally developed neurological signs with some serobiochemical alterations. It is concluded that camels may be one of the most sensitive species to salinomycin toxicity.
M.H. Al-Nazawi and A.M. Homeida, 2009. Kinetics and Tolerance of Salinomycin in Camels. Research Journal of Pharmacology, 3: 48-51.