Authors : Farhan Ahmad Khan and Hitesh Mishra
Abstract: This study was conducted to observe the in vivo effect of Cox-2 inhibition on immune response. Albino rabbits of either sex were divided into five groups of six animals, each were administered aspirin (100 mg kg-1, B.D., p.o.), celecoxib (30 mg kg-1 O.D., p.o.), indomethacin (12.5 mg kg-1 B.D., p.o.), etoricoxib (17 mg kg-1 O.D., p.o.) for 7 days starting 1 day prior to immunization by S. typhi antigen (0.5 mL in each thighs). The antibody titre were measured weekly for 1 month using Widal agglutination test. The antibody titres in the 1st week were raised in all the groups but the response was more marked in treated group as compared to control group. Later on antibody titre fell markedly in the treated groups. Selective Cox-2 inhibitors administration caused higher antibody suppression in comparison to non-selective Cox inhibitors treatment. These findings support that NSAIDs and the new Cox-2-selective drugs have an unsuspected target, the B cell and attenuate antibody production.
Farhan Ahmad Khan and Hitesh Mishra, 2011. A Comparative Study of Non-Steroidal Anti-Inflammatory Drugs on Immune Response with Special Reference to Cox-2 Inhibitors. Research Journal of Pharmacology, 5: 83-85.