Authors : S.M. Zamiul Rashid, M. Mominul Islam, Irfan Sajid, Bijan Kumar Karmaker and Md. Ekramul Haque
Abstract: To investigate the antidiarrheal activities of the methanolic extract of peel (MSPL) and pulp (MSPP) of Musa sapientum fruits, the extract was studied for antidiarrheal property using castor oil and magnesium sulphate induced diarrheal model and charcoal induced gastrointestinal motility as well as PGE2-induced enterolooping test in mice. In addition, activities against some causative diarrheal pathogenic bacteria were also determined. At the doses of 100 and 200 mg kg-1 body weight, both extracts significantly reduced the frequency and severity of diarrhea in test animals throughout the study period. Both extracts also showed a significant (p<0.001, 0.05) reduction in the gastrointestinal motility in charcoal meal test, as well as PGE2-induced intrafluid accumulation. MSPL extract also displayed strong antibacterial effect against against Staphylococcus aureus, Salmonella typhi, Shigella dysenteriae and Escherichia coli. Altogether, these results suggest that the Musa sapientum fruit extracts could be used as a potential antidiarrheal agent.
S.M. Zamiul Rashid, M. Mominul Islam, Irfan Sajid, Bijan Kumar Karmaker and Md. Ekramul Haque, 2013. Antidiarrheal Potentiality of Methanolic Extract of Different Parts of Musa sapientum Fruits. Research Journal of Pharmacology, 7: 41-47.