Authors : Adriana Sales , Andrea Lorenzo , Magdalena Rodriguez Areal , Patricia Marchisio and Leopoldo Sales
Abstract: Antacids are commonly used in self-medication for gastritis and duodenal ulcer treatments. Sodium levels present in antacids, an important factor in patients with hypertension or heart diseases, are not specified in leaflets. Neutralizing abilities of commercial products are not indicated either, which is fundamental for an adequate dosage. The aim of this work is to determine the aeutralizing ability (n.a) and the amount of sodium contained in a series of antacids, in their various pharmaceutical forms, available in the Argentinean market. Adequate dosage standards are indicated and a revision of leaflets is carried out. Neutralizing ability was determined by means of an acid-base volumetric technique, whereas sodium levels were determined by Atomic Absorption Spectrometry. N.a values between 12.82 and 24.83 meq per minimum dose were obtained. These values are within the range defined by the FDA (Food and Drug Administration) for a product to be admitted as "antacid". As regards the sodium contents found in the samples studied, values ranging from 0.1 to 11.0 mg of Na per minimum dose were obtained depending on the product brand name. According to the results, in only one case the sodium level obtained was outside the limits established. It is advisable to specify both n.a values and the sodium level in leaflets to avoid irrational use of this type of medication.
Adriana Sales , Andrea Lorenzo , Magdalena Rodriguez Areal , Patricia Marchisio and Leopoldo Sales , 2006. The Neutralizing Ability and Sodium Contents of Antacids. The Social Sciences, 1: 98-101.