Abstract: One of the effective educational tools is learning via e-technology. Screencast is a branch of e-learning. Although, screencast is extensively used in educational environments, presenting anesthesiology courses in Iranian university by this tool is a new approach. The present research aimed at comparing the effect of screencast in comparison with conventional education method (i.e., lecture) on learning, skill and satisfaction of anesthesiology students enrolled in bachelor’s degree in anesthesiology. The present research used pre-and post-test method with control group. The subject of “Invasive monitoring of systemic blood pressure and central venous pressure” was selected for this research due to its frequent use in cardiac surgery anesthesia. The sample included 47 students in senior years of bachelor’s degree in anesthesiology. They were divided randomly into two groups (screencast, N = 23 subjects) and control group (N = 24 subjects). The data collection tool consisted of a questionnaire of satisfaction as well as learning and skill tests. First, the learning pre-test was taken from both groups; the test group then received education during the semester by using screencast (independent variable) while control group was educated only in conventional form (professor lecture by using Power Point files). At the end, the data was collected by using learning test, skill and satisfaction on screen cast in pre- and post-test situations. The findings showed no significant statistical difference in students’ learning in both groups; however, significant difference was seen in the practical skills level and students’ satisfaction in test group in comparison with the control group. There was superiority of practical skills and satisfaction of students who had been under the effect of screen cast education based on Mayer principles. The lecturers and education policymakers are able to use the results of this research to select the modern teaching methods and merging them with educational modern technologies as per the case.