Abstract: The purpose of this study is to investigate the influence of cultural, religious, social, economic and political factors on non-textbook reading of the students and university students. The applied instrument was a questionnaire. Its reliability was measured by using SPSS Software. The value of Cronbach’s alpha for the university student’s questionnaire was 0.85 and 0.89 was achieved for the students. For analyzing the data, descriptive and inferential statistics were used. For the research hypotheses in the descriptive level, mean and standard deviation were calculated and in inferential analysis, multivariate regression analysis was applied. The findings of the study indicate that 33 and 27% of the studied population agreed about the high impacts of the Internet, lack of appropriate books and the lack of youth’s tendency towards non-textbook readings, respectively. On the other hand, the statistics show a significant relationship between the television advertising and tendency to non-textbook readings. The results also indicate that the impact of cultural, religious, social, economic and political factors on non-textbook reading of the students and university students of Mashhad. In addition, the results show that the multiple correlation coefficient (R) equals to 0.79 and the coefficient of determination (R2) equals to 0.62 in this analysis which show the social and cultural variables increase and express 62% of the changes of non-textbook readings variations among the collegians. Some solutions including increasing the communication between TV, radio and libraries, reducing the books audit and its final price, keeping pace with technology are presented in this study.