Abstract: The altered lipid metabolism in the placenta that is due to high maternal blood cholesterol, causes the mother and fetus deterioration. Thus, we investigated the effect of cholesterol-methionine enriched diet on serum, cardiac lipids and oxidative stress parameters of female rabbits and their offsprings. We analyze the effects of different diets administered to females 15 days before the mating and during 2 pregnancies on cardiovascular tissues and on their relative offsprings (first and second pregnancies). Thus, 3 lots are composed, a control group fed with Standard Diet (SD), one fed with cooking Oil enriched Diet (OD) and one with 1% cholesterol-0,25% Met enriched Diet (CD). Results show that CD causes newborn body weight reduction, reducing survival rate. In female plasma, total cholesterol, PL, HDL-C and LDL-C increase with CD. In plasma CD newborn, glucose and HDL-C decrease while PL and LDL-C rise. Pro-oxidant factors, MDA, AOPP, NO and anti-oxidant factors, UA, AOA, Vit C rise in CD female. Newborns subject to CD present modifications of MDA, NO, UA, AOA, Vit C, Catalase activity and Iron. In newborn cardiac tissue, OD and CD rise cholesterol and TG. The PL vary with OD. Analysis of cardiac lipids by TLC shows the involvement of PL, specialy phosphatidyl choline, lysophosphatidyl choline and sphingomyelin. In cardiac CD newborn we found a decrease of conjugated dienes, CAT, MDA and an increase of iron. Our study indicates the negative effects of CD (Chol+Met) ingested by female rabbit on serum, cardiovascular lipids and oxidative stress factors of their offspring.
S. Ait-Benali, K. Othmani-Mecif and Y. Benazzoug, 2015. Impact of Cholesterol-Methionine Diet on Serum and Cardiovascular Oxidative Stress Parameters of Female Rabbit and Their Newborn. Veterinary Research, 8: 13-26.