Abstract: Medical image registration is the process of aligning two or more images that represent the same anatomy at different times from different viewing angles or using different sensors. It geometrically aligns two images the reference and floating images. FPGA technology is used to improve performance while providing programmability and dynamic configurability. This study provides the evaluation of different kind of design and implementation of image registration using FPGA (Field Programmable Gate Array). This research focuses on performance, computational complexity, area required and power utilization of different algorithms on FPGA. The goal of this evaluation is not to determine an overall best method but to present a comprehensive catalogue of methods in a uniform terminology to define general properties and requirements of local techniques and to enable the reader to select that method which is optimal for a specified application in medical imaging.