Abstract: The aqueous extract of Carica papaya leaves were investigated for evaluation of wound healing potential in rats. Four groups of male Sprague Dawley rats each consist of 6 animals. All animals were experimentally wounded in the posterior neck area. Blank Vaseline was applied topically to wounds of Group 1 animals. Group 2 and Group 3 rats were treated topically with 5 and 10% Vaseline, respectively. Solcoseryl jelly was applied topically to wounds of Group 4 animals as a reference. The effects of vehicles on the rate of wound healing were assessed. Wounds treated with 5 and 10% Vaseline and wounds treated with solcoseryl jelly significantly accelerate wound healing potential compared to wounds treated with Blank Vaseline. These results strongly document the beneficial effects of plant extract for the acceleration of wound healing process in rats.