Abstract: P. major is used in many parts of the world for the treatment of diseases and to promote the healing of wounds. In the present study, the aqueous leaf extracts was evaluation for their cytoprotective activity against ethanol-induced gastric ulcers in rats. Grossly, oral administration of absolute ethanol to rats pretreated with distilled water significantly produced extensive damage of gastric mucosa, whereas animals pretreated with aqueous plant extracts significantly reduced the formation of gastric lesions compared to control group. Histologically, pretreated rats with aqueous extract showed significantly marked inhibition of gastric mucosal damage, marked reduction of submucosal oedema compared to control group. These results strongly document the beneficial cytoprotective effects of plant extract against ethanol-induced gastric ulcer in rats.