Abstract: The present study, was undertaken to assess the prevalence and pathology of brain disorders in cattle. The data collected from the autopsy records (99 bovine carcasses) maintained at the Center of Excellence in Pathology, College of Veterinary and Animal Sciences, Mannuthy, India and 52 brain samples obtained from both the slaughtered cattle and autopsy cases formed the basis of the study. The only gross lesion evident was meningeal congestion, which accounted to 70% of the cases. Congestion and hemorrhages were found consistently in the slaughtered cattle. The other major lesions were revealed by histopathological examination of 10 different areas of the brain in each case. These included vascular changes, neuronal degeneration, inflammatory changes, gliosis, pigmentation and neoplasia. Two cases revealed cytoplasmic inclusions of which one was due to rabies and the other was attributed to unknown viral etiology. Based on the observations made here, it is evident that incidence of pathological disorders encountered is relatively high. Thus, the need and scope for investigation into the pathological disorders of bovine brain warrants further investigation.