Abstract: A study of the perspectives and health implications of Female Genital Mutilation (FGM) was carried out in Amassoma, Bayelsa State, Nigeria. The purpose of this study was to describe the perspective of practice, perspective of knowledge and quality of life after FGM. A survey was conducted, using a four-stage probability sampling technique between April 2010 and June 2010. About 98.7% of the respondents were women of Ijaw ethnic nationality. About 99.3% have knowledge of the practice of FGM and 94% have witness this event and 48.6% were not satisfied with the practice of FGM and family members constitute 92% of the main source of consent influencing the practice of FGM. However, 2% was contributed by health professionals. The study reveals that the effect of FGM on intercourse was 2.7%; quality of life assessment on pain, hemorrhage, urinary retentions infections and complications after FGM was 1.3% among study respondents. The campaign and interventions of opponents of FGM should be focused on the family and particularly parents.