Abstract: Results of this study indicated that trypanosomosis is potential a serious threat to the health and productivity of goats in the study areas. Blood samples from 435 goats of different site, agro-ecology, color, sex and age group were collected conveniently and examine with parasitological techniques. Among the goats examined, infection prevalence was found to be as 46 out of 435 goats (10.57%). Most of the infection were due to T. congolense (5.1%) followed T. vivax (2.5%), the rest was due to T. brucei (1.8%), mixed infection of T. congolense and T. vivax (0.7%) and T. vivax and T. brucei (0.5%). There was no statistically significant difference between sex, age, color, treatment status as well as and the trypanosome species with infection rates. Statistically significant difference was observed between agro-ecology (χ2 = 5, p = 0.025) and study site (χ2 = 8.561, p = 0.014) with infection rates. Finally, the study revealed that trypanosomosis in goats is an important disease in the study area and attentions should be given for the prospect of the disease in goats.