Abstract: In Indonesia, lime (Citrus aurantifolia Swingle) juice is frequently used as a medicine for acute respiratory tract infection by mixing it with sweet soy sauce or honey. Therefore, a study aiming to know the influence of sweet soy sauce or honey addition toward antibacterial activity of lime juice at Salmonella aureus and S. pyogenes bacteria is conducted. At the beginning, lime juice is measured at its resistivity toward S. aureus and S. pyogenes bacteria. Then, the chosen concentration is mixed with sweet soy sauce or honey in different concentration. The result shows that lime juice concentration of 50% has a strong antibacterial activity with each value of MIC and MBC for S. aureus is 0.48 and 1.93% and for S. pyogenes is 0.59 and 2.97%. Sweet soy sauce or honey addition does not affect the antibacterial activity while the optimum concentration which can be added is 50%. Antibacterial activity of lime juice is indicated by cell wall damage which gives effect on lysis and morphological changes on bacterial cell.