Abstract: A study was conducted on 400 goats in Luna Export Abattoir originated from district area of Borena range land (i.e., Yabello and Negella) from November 2008 to April 2009 to estimate the prevalence of caseous lymphadenitis in goats. Detail post mortem examination and bacteriology were applied to undertake this study. On the bases of post mortem and bacteriological results; the prevalence of Caseous Lymphadenitis was 15% (60/400). Out of which 42 (70%), 13 (21.7%) and 5 (8.3%) were cutaneous, visceral and generalized form, respectively. There is statistical significance difference (p<0.05) among the three age groups. The study revealed that as age increases the prevalence increases. Statistical significant difference was also recorded between goats having poor and good body condition score (p<0.05). Moreover, goats with poor body condition score seem to be more infected (24.7%) than those goats with good body condition (12.5%). In conclusion, this study has indicated that CLA is prevalent in goats of Borena range land. Therefore, further extensive research should be conducted over all the country to determine prevalence and economic significance of the disease.