Abstract: Faith a significant impact on the human soul because confidence and her strength, patience and tolerance have increased the hardships of life and a sense of security and peace in his soul established and within comfort remember creates. Method of present study is descriptive and correlational. The study population included all of pregnant mother’s city of Susa in 2015 that of this number (50) were selected by simple random sampling. The tool measuring data include: religious orientation questionnaire (Allport), scale of Spiritual Experience (DSES) and self-esteem scale (Rosenberg). To analyze the data using statistical software SPSS and correlation coefficient and regression analysis were used. Pearson correlation coefficients showed that the spiritual experience and there is no significant relationship between self-esteem and also found that between self-esteem and there is a significant negative relationship between the religious orientation. Given the importance of the role of religion, mental health and physical recommended mothers in the promotion and fostering spirituality among of pregnant mothers more attention.