Abstract: Comparative efficacy of Aldazole, Fenvet and Ivomec Injection were investigated against natural infection with gastrointestinal nematodes of goats in Bangladesh. Ivomec injection showed maximum efficacy of 100% followed by Fenvet (95.35%) and Aldazole (90.11%) on the basis of reduction of faecal EPG recorded. The haematological studies at post treatment day A28@ shown that TEC (million/cu mm), Hb (gm%) and PCV (%) were significantly increased (P<0.01) than that of pretreatment day A0@ but ESR (mm 1hr-1) was decreased upto 100% in goats.