Abstract: Levamisole hydrochloride was orally administered at 3.75, 7.5, 15 and 30 mg kg-1 b.w. doses to different groups of broiler chicks on Day 7,8,9,28,29 and 30 along with the primary and booster inoculations of Ranikhet-La Sota and Sheep Red Blood Cells (SRBC) on Day 7 and 28. The Humoral immune response and serum proteins were observed. Levamisole hydrochloride in all dose levels tested showed elevated antibody titres against La Sota and SRBC and elevated total serum proteins and serum globulins.