Abstract: Skin sections of sheep inoculated with live spores anthrax vaccine revealed edema, intense effusion of mononuclear cells and proliferation fibroblast in the dermis and subcutaneous tissues, whereas sections of skin of those inoculated with capripox vaccine showed hyperplasia and hydrophopic degeneration of epidermal epithelium and instance infilteration of cellular exudates in dermis and subcutaneous tissues. However, the lesions presented by the combined vaccine included the fore mentioned lesions.