Abstract: An anthrax and sheep pox combined vaccine was made in a lyophilized form by mixing concentrated live spores of Bacillus anthracis (Sterne strain) of known count with sheep pox virus (0240 vaccine strain) of a known titer. It induced protection against anthrax in guinea pigs and sheep pox diseases in sheep after challenge with virulent Bacillus anthracis and sheep pox virus respectively. The vaccine was found stable after 15 month of preservation at -20�C.