Abstract: In this study, we describe the historical, clinical and microbiological features, as well as treatments and clinical outcome, of pyoderma, where Staph. aerus alone was isolated on bacterial culture from lesional skin. Skin lesions in cat consisted of erythematous papules, haemorrhagic bullae, ulcers and haemorrhagic crusts confined to the dorsum. An excellent clinical response was achived 10 days of treatment with parenteral Clindamycin.