Abstract: Varroa is one of the most dangerous honey bee parasites, which has caused serious damages to the bee industry. By now, various herbal and chemical drugs hard been used. In this research, the effect of 7 treatments including tobacco extract, harmel ext, thymus ext, tobacco smoke, harmel smoke and thymus smoke and also one control group each with three replicate in a completely randomized design (CRD) have been examined on 21 colonies. The whole period of experiment was five days. The rate of hive contamination at the beginning and end of the experiment along with daily rate of varroa and worker bee contamination were recorded. There was no significant difference between experimental hives at the beginning of the study. However, significant dissimilarity was found between experimental treatments at the end of period (p<0.05). Considering the rate of the mortality of varroas in different days and the whole period of the study, a significant different was observed (p<0.05) and tobacco ext. had the largest effect on the varroa control. Besides, significant dissimilarities in the mortality of the bees were found in various days nad considering this aspect, harmel ext had the highest effect.