Abstract: In the present study, seroprevalance of Q fever in sheep in the region of Van was aimed to investigate. A total 465 serum samples obtained from the city of Van and its different provinces were investigated with regard to Q fever specific antibodies using ELISA technique. Out of 465 serum sample 98 of them (21.07%) were found to be positive and 11 of them (2.37%) were doubtful with regard to Q fever specific antibodies.