Abstract: Fishes are largely used for the assessment of aquatic environment quality and are accepted as bioindicators of environmental pollution. This study evaluated haematological and biochemical responses of Capoeta trutta captured in Munzur River, Tunceli, Turkey. Blood and biochemical parameters (Sodium (Na), Potassium (K), Calcium (Ca), Phosphorus (P), Chlorine (Cl) and Iron (Fe)) were determined. The values of Red Blood Cell (RBC) Haemoglobin (Hb), Haemotocrit (Ht), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), Platelet Count (PLT), Mean Platelet Volume (MPV), Plateletcrit (PCT), Platelet Distribution Width (PDW) from examined haematological parameters were found as 0.67±0.09 1012 L-1, 13.5±0.90 g dL-1, 14.78±0.19%, 218.40±4.29 fL, 194.75±15.36 pg, 108.52±1.09 g dL-1, 34.12±5.89 109 L-1, 11.92±1.65 fL, 0.061±0.01% and 19.77±1.71 fL, respectively. The values of Fe, Cl, P, Ca, K and Na from examined biochemical parameters were determined as 91.75±28.27 g dL-1, 92.00±4.02 mmol L-1, 13.20±1.26 mg dL-1, 11.65±0.74 mmol L-1, 1.30±0.21 mmol L-1 and 132.5±3.90 mg dL-1 respectively. Observation of blood parameters allows the most rapid detection of changes in fish after the exposure to xenobiotics. It can conclude that hematological and biochemical parameters could be ranked as possible biomarkers of pollution.