Abstract: For a number of years, coenzyme Q was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in plasma and extensively investigated its antioxidant role. Coenzyme Q levels are also affected during aging and neurodegenerative diseases. Very few studies have been carried out to know effects of dietary coenzyme Q in wild type animals. Acetyl-l-carnitine facilitates the uptake of acetyl-CoA into the mitochondria during fatty acid oxidation. Acetylcarnitine supplementation has beneficial effects in elderly animals and humans. In current study, the effects of coenzyme Q10 and acetyl-l-carnitine in antioxidant enzyme activities and protein amounts were investigated. The use of coenzyme Q10 and acetyl-l-carnitine, two important component related with mitochondria as food supplements have similar effects in terms of antioxidant enzyme activities and protein amount of organism.