Abstract: Phytochemical and bioactivity studies of Teucrium persicum Boiss. have been investigated on the aerial parts of the plant. About 2 flavonoids, 5-hydroxy 3, 7, 4-trimethoxyflavone and 5-hydroxy 7, 3′, 4′-trimethoxyflavone were purified and identified from chloroform partition by spectroscopy methods. The crude extracts and isolated compounds were screened for their antioxidant activities using DPPH radical-scavenging, FRAP and Reducing power methods. Methanol extract and isolated flavonoids were found to be the most antioxidant active portions.