Abstract: The seroprevalence of Toxoplasma gondii infection in slaughter pigs in Sichuan province, Southwestern China was investigated between May and November, 2010. A total of 803 serum samples from slaughter pigs were collected from seven different counties in Sichuan province and assayed for T. gondii antibodies by Indirect Haemagglutination (IHA) test using a commercially available kit. The overall seroprevalence was 29.51% (237/803), ranging from 9.3-37.91% among different sampling regions. The results of the present survey indicated that the seroprevalence of T. gondii infection in slaughter pigs in Sichuan province is relatively high and consumption of pork may be a risk factor for human infection with T. gondii. Therefore, improved integrated strategies for the control of the parasite should be implemented to reduce the prevalence levels in the surveyed areas.