Journal of Animal and Veterinary Advances

First Report on Rotenoids as Neurotoxic Principles of Seeds from Aeschynomene indica (Leguminosae)

Andreia O. Latorre, Giovana A. Borghi, Patricia L. Lopes, Kelly C. Higa, Lucia M.X. Lopes, Paulo C. Maiorka, Silvana L. Gorniak and Mitsue Haraguchi

Abstract: Toxic principles from seeds of Aeschynomene indica collected in Brazil were analyzed. Dalpanol, 12 α-hydroxydalpanol and 11-hydroxydalpanol were identified using ¹H NMR in A. indica for the first time. 11-hydroxydalpanol has not been previously reported in the existing literature. Furthermore these rotenoids are likely the toxic principles that cause neurological signs in mice.