Abstract: The present study aimed to investigate the effects of Corn Oligopeptides (COP) on acute alcoholism in rat models. Female SD rats were randomly assigned to 4 groups per test including control group and 3 COP intervention groups (2.25, 4.5 and 9 g/kg/BW). About 5 g/kg/BW ethanol (8 g/kg/BW for loss of righting reflex test) was given intragastricly 10 min before COP treatment. Ethanol levels in blood, behavioral studies and ADH activity in liver were assayed. Researchers found that COP treatment could promote the alcohol metabolism and correct the movement disorder caused by alcohol consumption to some extent. However, the ADH levels had no changes among different groups. These findings suggest that COP have a protective effect on acute alcoholism in rats.