Abstract: NSP is the major factor introducing a low digestibility of cottonseed meal in piglets. The present study was conducted to determine the effect of NSP enzyme on the nutrient digestibility of weaned piglets fed a cottonseed meal-based diets. About 15 weaned piglets (14±1.4 kg) were selected and ileal fistula surgery was done to determine the DE, CP, DM and NSP’s apparent digestibility. The results indicated that NSP enzyme improved piglet’s apparent digestibility (p<0.05) in varying degrees; pectinase resulted in obvious degradation of the cell wall and increased piglets’ DE (26.69%) and CP of ileal digesta (20.33%) and compound enzyme was better in improving cottonseed meal based diets than single enzyme.