Abstract: In this study, the concentrations of heavy metals (Cd, Cr, Cu, Fe, Mn, Pb and Zn) were determined in gastral, tentacular and epidermal (umbrella) tissues of jellyfish Ropilema nomadica from 2 stations (Yumurtalik and Arsuz) in Iskenderun Bay, Turkey. Heavy metal concentrations varied significantly depending on the type of the tissue and location of stations. The average metal concentrations in gastral and tentacular were found higher than umbrella tissues in all samples. The level of Mn and Zn concentrations were significantly different among the tissues in both stations (p<0.05). The aim of this study was to imply potential of heavy metal accumulation in jellyfish which plays an important role in biological transfer and Summer blooms. Moreover, this is the first study of the heavy metal bioaccumulation on R. nomadica in Northeastern Mediterranean.