Abstract: Once a mammal infected by a microorganism an elaborate response will be generated that attempts to eliminate the infection agent. These responses contained innate immune responses and adaptive immune responses. Cytokines played a role in both innate and adaptive immune responses. Porcine circovirus type 2 was the causal agent of postweaning multisystemic wasting syndrome which was an economically important disease in pigs. Although, the interaction between immune responses and porcine circovirus was suggested as a determinant factor in the pathogenesis of postweaning multisystemic wasting syndrome, the reports about the cytokines profile in PCV2 infection were mixed and confused. Thus, a detailed review about this field was presented according to the literature and the lab’s conclusion.