Abstract: Fundamental studies of modern medical and veterinary science, advances in the knowledge of the multifaceted aspects of the relationship of macro and microorganisms allowed developing and introducing new biologics class probiotics which are based on live microbial cultures that have complex properties beneficial to the microorganism. The problem of sanitation, safety and productivity of the animals as well as get full on the biological quality of livestock products with probiotics is very promising, it requires profound both basic and applied research in biotherapy problem with the use of live cultures of micro-organisms that make up the human bodys and animals normal ecological community. The use of bio-safe products-probiotics become a priority in the livestock industry of Kazakhstan.