Abstract: Emphysematous Pyelonephritis (EPN) is an infection of the renal parenchyma and perinephric tissue which resulted in the presence of gas in the collecting system, renal parenchyma or perinephric tissue. Researchers presented three cases of EPN and performed a comprehensive review of the literature on EPN to describe and summarize the causation, clinical manifestation, diagnosis, treatment and prevention. Early diagnosis is essential for a positive outcome. A high index of suspicion coupled with a good imaging study of the abdomen can lead to early diagnosis and optimizing management modality which are fundamental for a favorable outcome.