Abstract: To determine the capability for infection and pathogenicity of Newcastle Disease Virus (NDV) in pigs and chicken, researchers used two NDVs (Xiny from pigs and virulent strain F48E9) to infect weaned piglets and Specific Pathogen-Free (SPF) chicken artificially. Results showed that strains F48E9 and Xiny were inadequately virulent to cause piglet illness or death. However, the virus agents are detectable in the pig body. F48E9 can cause the death of SPF chickens but Xiny caused no pathology in such chickens.