Abstract: New naringenin derivatives bearing halogen moiety (1-6) were designed and synthesized. The structure of the newly synthesized compounds was elucidated by elemental analyses and spectral data. The in-vitro antimicrobial activity of the obtained compounds has been evaluated. All new analogues tested show inhibitory activity against microorganisms under investigation, the most potent compounds are 1-4. The rest of compounds show nearly same antimicrobial activity as ciprofloxacin reference drug used in this study. The new analogues showed also augmentation effect when used together with ciprofloxacin.