Abstract: A novel compact Minkowski Pre-fractal antenna is investigated to be an efficient scheme of miniaturization. Based on the simulation results, the proposed antenna has shown to posses an excellent size reduction possibility with good radiation performance for wireless applications. Compared with the conventional square patch microstrip antenna and the square microstrip antenna with two pairs of slits at edges, the presented antenna exhibits high size reduction, wider impedance-bandwidth performance and multi-frequency operation with acceptable radiation characteristics. Moreover, with the novel geometry, the designer will have a high degree of freedom that can be used to reduce further the antenna size.