Abstract: This study presents an analysis of the parameters that affect the performance of a rotary wheel desiccant dehumidifier, when used as a component of an evaporative-adsorptive system applied to air conditioning for comfort. The temperature and moisture of the process and reactivation airflows, the air velocity through the dehumidifier, the reactivation temperature and the Reactivation and Process airflow ratio (R/P) are analyzed. The analysis is made on a dehumidifier available in the market, by means of two softwares of adsorption dehumidifier equipment manufacturers. It is concluded, among other results, that lower reactivation temperatures and lower R/P relationship give the process air a better thermodynamic condition for the desirable application.