Abstract: The renewable energy potential of coastal areas of Tamil Nadu, India ranks among the highest in the world. The annual solar energy received is 5.0 kWh m-2 and the wind energy received is at a moderate speed (4-6 m sec-1). This study proposes optimization and cost of energy of different hybrid renewable energy system to power a health clinic in that building. The total daily health clinic load is 34.9 kWh and detailed loads are listed. The National Renewable Energy Laboratory (NREL) optimization computer model for distributed power, homer is used to estimate the optimization and its cost of energy. The implementation of RE systems to supply rural health clinics will contribute to reduce both electricity generation cost and CO2 emissions while improving health care and quality of life in these isolated coastal regions.