Abstract: The enhancements in employees’ quality of working life of health information technology not only increase the quality of health services but also help to promote health information system. The aim of this study was to answer this question: what is the status of the quality of working life of these employees. This study was performed in affiliated hospitals of Semnan University of medical sciences in Semnan, Iran in 2015. In this study, a census method was used. The data collection tool was a researcher made questionnaire. The 36.6% were satisfied with safety of their work environment. The 82.2% feel safe of their working environment, 43.6% believed there was general supervision on staff. It is concluded that health information staffs’ job was somewhat attractive and multi facet; it might help them to enhance their quality of working life.