Abstract: Vibrio harveyi is one of the important aquatic pathogens founded predominately in marine habitats. The gram-negative bacterium can cause infection in a broad range of marine vertebrates and invertebrates, involving fishsh, shrimp, lobster and mollusk. Until now, the traditional forms of vaccines against V. harveyi have been produced including killed whole bacterial cells (mostly) and extracellular products (in part). In addition to these vaccines, currently a number of protein-based (in fact recombinant subunit) vaccines have been manufactures and are shown to be effective against some V. harveyi starins.