Abstract: Leptospirosis is a widespread zoonosis caused by members of the genus Leptospira. These highly invasive spirochetal pathogens are capable of infecting a broad range of mammalian hosts through either direct contact with an infected animal or indirect contact with soil or water contaminated with urine from a chronically infected animal. In humans, acute leptospirosis accounts for roughly 10% of hospitalizations for acute febrile illness in tropical areas of the world.