Abstract: Mobile health (mHealth) applications attempt to capitalize on the ubiquity and exponential growth of mobile technologies for the benefit of public health, leading to a growing research interest in devising frameworks for addressing specific or general mHealth challenges. In this context, the primary goal of this study is to present a novel smartphone-based development framework for prototyping vision-aware native mHealth applications developed using Feature Driven Development (FDD) methodology. Then, we describe a prototype mHealth educational application, ‘Dibdib’** Advocacy App for breast cancer awareness, utilizing the proposed vision-aware mHealth framework in Android platform. The results illustrate that FDD is feasible option in mHealth application development under the proposed mHealth framework.