Abstract: We studied diuretic and saluretic effects of new synthetic origin phenolic glycosides and their aglicones. Investigation of diuretic and saluretic activity of of 4-nitrophenyl-β-D-glucopyranoside, hydroquinone-O-β-D-glucopyranoside (arbutin) and their aglycon-4-nitrophenol and hydroquinone was conducted on white laboratory rats in vivarium Animals received drug 7 days. Baseline diuresis after administration of 2 mL of distilled water of experimental group accepted as a control. The quantity of urine output was measured a day after administration of the test substances. The concentration of sodium and potassium ions in the urine were determined by flame photometry. The data obtained indicate that investigated glycosides has high diuretic activity. Phenolic glycosides have a pronounced diuretic effect as opposed to their aglycones in rats.