Abstract: The research is dedicated to addressing the issue of joint processing of geotechnical and geodynamic monitoring data of Karst processes. Based on geotechnical monitoring of the real object which is located in the Karst terrain, it highlights the main problems affecting the quality of the forward-looking estimates. It was found that for increasing the sensitivity of detecting the initial phase of destructive processes in the “geological environment engineering facility” system, it is necessary to use the several informative control methods (geoelectrical, inclinometric, strain gauge). The structural scheme and algorithm of joint processing of geotechnical and geodynamic monitoring data. The block-diagram assumes allocation of the key geodynamic objects, the algorithms of distributed processing of the heterogeneous data and the formation of forward-looking estimates. The techniques of the registration and initial processing of physical parameters on the basis of selected informative methods are described. The numerical solution of the deformation interaction problem in the “subsoil-foundation-structure” system is carried on the basis of geotechnical and geodynamic monitoring data.